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Enflnrane was introduced as a general anesthetic agent in 1972. Anesthesiologists hoped that it might prove a valuable addition to other agents used heretofore. So far, information on clinical studies of Enflurane on human patients under surgical conditions is very limited. Therefore, the writer studied the effects of Enflurane on the cardiovascular system, central nervous system, neuromuscular system, and renal and hepatic function in surgical patients under the 3% Enflurane-O_2 anesthesia. The results were as follows; 1) MEAN arterial pressure were stabilized during the operative period, except at the endotracheal intubation, and heart rate were incerased by about 23 percent without showing any abnormal changed in the ECG findings. 2) There was no specific abnormal changes in the EEG findings. 3) Twitch depression were increased progressively according to the depth of Enflurane anesthesia. After 60 minutes of anesthesia, the effects of twitch depression were about 55 percent. 4) Compared to the control values, postoperative blood chemistry for live and renal function did not show any significant changes. 5) During the recovery from anesthesia, a mild shivering was observed in some patients, but other complications during the postoperative period were not observed.
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